Table 4 Top thrombosis related pathway obtained from the enrichment analysis of the genes associated with the interacting PPI of the HIF and DNMT family genes.
From: micro-RNAs dependent regulation of DNMT and HIF1α gene expression in thrombotic disorders
GSEA | Pathway/Term ID | Overlap | Associated genes | GSEA library | AdjP-value |
|---|---|---|---|---|---|
Enriched Thrombosis associated pathways | |||||
Hemostasis | R-HSA-109582 | 33/552 | APP;HDAC2;SPARC;KDM1A;SHC1;SRC;HDAC1;SERPINE1; GATA5;GATA4;ARRB1;SLC7A11;GATA2;SIN3A;KCNMB1; LAMP2;AKT1;TIMP3;EP300;CREBBP;CBX5;HSPA5;NOS3; F12;YWHAZ;VEGFA;TF;MAFG;KIF4A;PTPN6;MAFK; ALDOA;TP53 | Reactome | 7.19E-08 |
Angiogenesis | P00005 | 13/142 | GSK3B;JUN;NOTCH1;SHC1;NOS3;SRC;STAT3;ETS1; VEGFA;APC;AKT1;CTNNB1;EPHB1 | Panther | 2.52E-05 |
NF-kappa B signaling pathway | hsa04064 | 10/93 | PIAS4;UBE2I;CSNK2A1;PARP1;CSNK2B;BCL2; IRAK4;RELA;RELB;BCL2L1 | KEGG | 5.11342E-05 |
VEGF, Hypoxia, and Angiogenesis | h_vegfPathway | 08/302 | HSP90AA1;NOS3;SRC;SHC1;ARNT;AKT1;VHL;VEGFA | Biocarta | 6.10235E-07 |
TPO Signaling Pathway | h_TPOPathway | 05/42 | STAT5A;JUN;CSNK2A1;SHC1;STAT3 | Biocarta | 0.000280854 |
