Table 3 Comparison of all DM patients between the D-dimer <1 μg/mL group and D-dimer ≥1 μg/mL group.

From: Elevated plasma D-dimer levels in dermatomyositis patients with cutaneous manifestations

 

All DM patients: n = 150

P-value

D-dimer <1 μg/mL: n = 51

D-dimer ≥1 μg/mL: n = 99

VTE

0

11

0.016

malignancy

1

17

0.007

infection

3

20

0.029

other CTD

12

14

0.175

cutaneous manifestations

13

65

<0.001

CPK (IU/L)

58.0 (36.0, 104.0)

49.0 (24.5, 150.5)

0.260

KL-6 (U/ml)

311 (222, 609)

361 (244, 725)

0.440

age (years)

56.5 (40.5, 60.3)

65 (53.0, 74.0)

<0.001

PLT (×104/μl)

23.1 (20.4, 30.1)

21.5 (16.7, 29.0)

0.034

PT (s)

11.2 (10.6, 11.8)

11.2 (10.5, 11.7)

0.635

APTT (s)

28.5 (26.7, 31.5)

27.1 (24.8, 29.3)

0.021

CRP (mg/dl)

0.070 (0.020, 0.20)

0.20 (0.060, 1.13)

<0.001

LDH (IU/l)

219 (193, 263)

286 (214, 420)

<0.001

dose of steroid (prednisolone, mg)

7.5 (5.0, 18)

20 (8.0, 30)

0.002

duration of steroid (years)

4.9 (0.16, 11)

0.28 (0.038, 6.5)

0.014

total dose of steroid (prednisolone, mg)

16048 (1146, 34072)

5943 (463, 26277)

0.070

  1. The data are presented as the median (Q1, Q3). DM, dermatomyositis; VTE, venous thromboembolism; CTD, connective tissue disease; CPK, creatine phosphokinase; PLT, platelet; PT, prothrombin time; APTT, activated partial thromboplastin time; CRP, C-reactive protein; LDH, lactate dehydrogenase.
  2. Normal values: D-dimer, <1.00; CPK, 59–248; KL-6, 105–435; PLT, 15.8–34.8; PT, 9.8–12.1; APTT, ≤37; CRP, ≤0.14; LDH, 124–222.