Figure 1

Indomethacin induces SI epithelial injury. (a) WT mice were subcutaneously injected with indomethacin (IND) (15 mg kg⁻¹ body weight) or vehicle alone (100 μl/mouse). Body weight loss from initial body weight is shown. Data are given as mean ± s.d. (Control; N = 3, IND; N = 8). *P < 0.05 by 2-Way ANOVA followed by Bonferroni post-hoc test. (b) Fluorescein-isothiocyanate (FITC)-labeled dextran was administered by oral gavage. Leakage of FITC-dextran from the gut was measured (in serum) one hour post administration. Assays were performed on indicated days post IND injection. Data are given as mean ± s.d. (N = 5). Dots indicate individual mice. N.S.; not significant, *P < 0.05 by Dunnett test. (c) SI endoscopy was performed on indicated days post IND injection. Representative endoscopic images are shown.