Table 4 Top 10 Reactome enriched pathways for MDS preserved critical driver proteins between the normal/uninfected and HIV-1 infected network.
Pathway name | Total proteins in pathway | Matching proteins | p-value | FDR |
|---|---|---|---|---|
Toll-Like Receptor Cascades | 141 | 14 | 9.27E-06 | 1.23E-04 |
Signalling by Interleukins | 460 | 43 | 1.15E-14 | 2.21E-12 |
CD28 co-simulation | 29 | 6 | 8.01E-05 | 5.61E-04 |
Fc epsilion receptor (FCERI) signalling | 405 | 32 | 2.96E-09 | 1.75E-07 |
Signalling by B Cell Receptor (BCR) | 270 | 23 | 1.68E-07 | 5.89E-06 |
Signalling by NGF | 421 | 45 | 1.11E-16 | 5.30E-14 |
Signalling by PDGF | 328 | 33 | 3.32E-12 | 3.52E-10 |
Signalling by Wnt | 230 | 20 | 8.29E-07 | 2.24E-05 |
Intrinsic Pathways for Apoptosis | 41 | 10 | 7.61E-08 | 2.89E-06 |
SMAD heterotrimer regulates transcription | 32 | 7 | 1.43E-05 | 1.57E-04 |
