Table 7 Protein-protein interaction enrichment analysis for top 200 genes picked from RF and FRF using the whole genome statistical background with a minimum interaction score of 0.15.
From: Functional random forest with applications in dose-response predictions
Drug | Model | #Nodes | #Edges | Expected #edges | Ratio of observed to expected #edges | PPI enrichment p-value |
|---|---|---|---|---|---|---|
Erlotinib | RF | 107 | 132 | 127 | 1.04 | 0.356 |
FRF | 105 | 170 | 142 | 1.20 | 0.013 | |
Nilotinib | RF | 102 | 185 | 162 | 1.14 | 0.044 |
FRF | 101 | 173 | 144 | 1.20 | 0.010 | |
PD-0325901 | RF | 107 | 191 | 187 | 1.02 | 0.407 |
FRF | 113 | 153 | 139 | 1.10 | 0.134 | |
PLX-4720 | RF | 106 | 159 | 147 | 1.08 | 0.164 |
FRF | 111 | 217 | 187 | 1.16 | 0.018 | |
TAE-684 | RF | 103 | 159 | 141 | 1.13 | 0.078 |
FRF | 106 | 180 | 151 | 1.19 | 0.011 |
