Table 1 Basic characteristic of 30 studies included in Meta-analysis.
First author(year) | Study region | Inclusion time | Treatment | Metformin user/total patients | Study design | Study setting | Outcomes | Article type |
|---|---|---|---|---|---|---|---|---|
Mayer 201716 | Canada | 2005–2012 | Docetaxel | 359/2832 | Retrospective Cohort | Population-base | OS CSS | Full |
Zaorsky 201757 | USA | 1998–2013 | Radiotherapy | 251/3217 | Retrospective Cohort | Hospital-base | OS CSS RFS | Full |
Richards 201717 | USA | 2000–2015 | ADT | 14517/87344 | Retrospective Cohort | Population-base | OS CSS | Abstract |
Jarrard 201758 | USA | N/A | Mix therapy | 68/788 | Prospective Cohort | Population-base | OS | Abstract |
Haggstrom 201739 | Sweden | 2006–2013 | N/A | 10224/612846 | Prospective Cohort | Population-base | Incidence | Full |
Chen 201749 | Canada | 1994–2012 | N/A | 35829/44172 | Retrospective Cohort | Population-base | Incidence | Full |
Haring 201743 | Finland | 1995–2009 | N/A | 8989/78615 | Prospective Cohort | Population-base | Incidence | Full |
Chong 201659 | USA | N/A | Mix therapy | 138/287 | Retrospective Cohort | Hospital-base | OS RFS | Full |
Joentausta 201660 | Finland | 1995–2009 | Prostatectomy | 133/1314 | Retrospective Cohort | Population-base | OS RFS | Full |
Wang 201648 | USA | 2003–2012 | N/A | 29805/76733 | Retrospective Cohort | Population-base | Incidence | Full |
Raval 201640 | USA | 2008–2009 | N/A | 938/2652 | Retrospective Cohort | Population-base | Incidence | Full |
Xu 201561 | USA | 1995–2010 | Mix therapy | vanderbilt: 218/32415 Mayo: 3029/79258 | Retrospective Cohort | Hospital-base | OS | Full |
Randazzo 201562 | Swizerland | 1998–2003 | Mix therapy | 150/4314 | Prospective Cohort | Population-base | OS | Full |
Lee 201563 | Korea | 2006–2013 | Prostatectomy | 135/746 | Retrospective Cohort | Hospital-base | RFS | Full |
Reznicek 201564 | USA | 2002–2010 | Mix therapy | N/A/1155 | Retrospective Cohort | Hospital-base | OS | Abstract |
Lu-Yao 201552 | USA | 2007–2009 | Mix therapy | N/A | Retrospective Cohort | Population-base | CSS | Abstract |
Danzig 201565 | USA | 1987–2010 | Prostatectomy | 98/767 | Retrospective Cohort | Hospital-base | RFS | Full |
Nordstrom 201541 | Sweden | 2007–2012 | N/A | 7678/185667 | Retrospective Cohort | Population-base | Incidence | Full |
Feng 201542 | USA | N/A | N/A | 194/693 | Prospective Cohort | Population-base | Incidence | Full |
Rieken 201466 | USA and Europa | 2000–2011 | Prostatectomy | 287/6486 | Retrospective Cohort | Hospital-base | RFS | Full |
Bensimon 201454 | UK | 1998–2009 | Mix therapy | 242/935 | Retrospective Cohort | Population-base | OS CSS | Full |
Spratt 201455 | Canada | 1992–2008 | Radiotherapy | 157/319 | Retrospective Cohort | Hospital-base | OS CSS RFS | Full |
Taira 201421 | USA | 1995–2010 | Radiotherapy | 126/2298 | Retrospective Cohort | Hospital-base | OS RFS | Full |
But 201453 | Finland | 1997–2010 | N/A | 1188/23394 | Retrospective Cohort | Population-base | Incidence | Full |
Habel 201451 | USA | 1997–2009 | N/A | N/A | Retrospective Cohort | Population-base | Incidence | Abstract |
Onitilo 201467 | Australia | 1995–2009 | N/A | 5679/9468 | Retrospective Cohort | Population-base | Incidence | Full |
Tseng 201468 | China | 1998–2002 | N/A | 186212/395481 | Retrospective Cohort | Population-base | Incidence | Full |
Zannella 201369 | Canada | 1996–2012 | Radiotherapy | 114/504 | Retrospective Cohort | Hospital-base | RFS | Full |
Margel 201370 | USA | 1997–2008 | Mix therapy | 1251/3837 | Retrospective Cohort | Population-base | OS CSS | Full |
Magliano 201271 | Australian | 1993–2010 | N/A | N/A/2258 | Retrospective Cohort | Population-base | Incidence | Full |
