Table 2 Markers with higher NPX values in pregnancy.

From: Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum

	Pregnancy			Postpartum			Mean difference	Linear Mixed model^*	Linear mixed model Bonferroni p-value*
	n	Mean	SD	n	Mean	SD	Mean difference	Linear Mixed model^*	Linear mixed model Bonferroni p-value*
LIF-R	198	4.91	0.54	114	1.77	0.27	−3.14	0.000	0.000
LAP TGF-beta-1	198	7.70	0.52	114	5.29	0.35	−2.41	0.000	0.000
CCL28	198	3.71	0.89	114	1.57	0.50	−2.14	0.000	0.000
OSM	198	3.73	0.99	114	1.89	0.73	−1.84	0.000	0.000
FGF21	198	4.35	1.91	114	2.52	1.28	−1.83	0.000	0.000
HGF	198	6.87	0.46	114	5.42	0.29	−1.44	0.000	0.000
uPA	198	11.05	0.35	114	9.71	0.24	−1.34	0.000	0.000
CDCP1	198	2.75	0.56	114	1.42	0.41	−1.33	0.000	0.000
IL-10RB	198	6.27	0.39	114	4.95	0.30	−1.32	0.000	0.000
OPG (TNFRSF11)	198	10.60	0.56	114	9.30	0.30	−1.29	0.000	0.000
CSF1	198	7.91	0.29	114	6.89	0.23	−1.03	0.000	0.000
FGF23	198	2.53	1.01	114	1.54	0.48	−1.00	0.000	0.000
IL-17C	198	1.78	0.63	114	0.79	0.66	−0.98	0.000	0.000
SIRT2	198	3.81	1.36	114	2.83	1.04	−0.98	0.000	0.000
IL-18R1	198	6.44	0.49	114	5.48	0.40	−0.97	0.000	0.000
IL-18	198	7.53	0.60	114	6.59	0.49	−0.94	0.000	0.000
IL-6	198	2.33	0.75	114	1.39	0.69	−0.94	0.000	0.000
STAMBP	198	3.70	1.19	114	2.96	0.83	−0.75	0.000	0.000
CXCL10	198	8.68	0.91	114	8.04	0.78	−0.64	0.000	0.000
CXCL11	198	7.00	0.93	114	6.37	0.75	−0.63	0.000	0.000
MMP1	198	1.55	0.99	114	0.94	0.85	−0.61	0.000	0.000
4E-BP1	198	5.05	1.07	114	4.47	0.77	−0.58	0.000	0.000
AXIN1	198	2.78	1.56	114	2.21	1.21	−0.57	0.000	0.007
CASP8	198	0.69	0.75	114	0.14	0.41	−0.56	0.000	0.000
VEGF-A	198	10.18	0.33	114	9.67	0.33	−0.51	0.000	0.000
Beta-NGF	198	0.87	0.38	114	0.37	0.21	−0.49	0.000	0.000
Flt3L	198	8.54	0.43	114	8.05	0.39	−0.49	0.000	0.000
TNFSF14	198	0.98	0.60	114	0.49	0.35	−0.49	0.000	0.000
CCL3 (MIP-1-alpha)	198	1.87	0.63	114	1.38	0.39	−0.49	0.000	0.000
IL-10	198	2.65	0.75	114	2.16	0.66	−0.48	0.000	0.000
IL-7	198	2.14	0.64	114	1.65	0.48	−0.48	0.000	0.000
ADA	198	4.78	0.64	114	4.31	0.32	−0.47	0.000	0.000
CD40	198	8.38	0.64	114	7.92	0.43	−0.46	0.000	0.000
hGDNF	198	1.67	0.49	114	1.22	0.41	−0.45	0.000	0.000
IL-15RA	198	0.31	0.33	114	−0.12	0.35	−0.43	0.000	0.000
TGF-alpha	198	0.44	0.45	114	0.02	0.20	−0.42	0.000	0.000
CCL4	198	4.48	0.57	114	4.13	0.54	−0.35	0.000	0.000
DNER	198	6.46	0.42	114	6.18	0.21	−0.28	0.000	0.000
CX3CL1	198	5.11	0.49	114	4.84	0.34	−0.27	0.000	0.000
CST5	198	5.18	0.42	114	4.95	0.45	−0.22	0.000	0.000
LTA (TNFB)	198	2.87	0.53	114	2.71	0.38	−0.16	0.000	0.031
CXCL1	198	7.89	0.86	114	7.57	0.82	−0.31	0.002	0.123
FGF5	198	0.54	0.37	114	0.48	0.47	−0.05	0.008	0.569
FGF19	198	7.20	0.93	114	7.05	0.93	−0.16	0.185
CXCL6	198	6.43	0.81	114	6.34	0.68	−0.09	0.434
CCL25	198	5.25	0.69	114	5.17	0.54	−0.08	0.261
CD244	198	5.24	0.47	114	5.17	0.38	−0.07	0.060
TNFRSF9	198	5.39	0.41	114	5.36	0.32	−0.03	0.373
IL-8 (CXCL8)	198	4.72	0.61	114	4.69	0.58	−0.03	0.796
NT-3	198	1.71	0.73	114	1.71	0.58	−0.001	0.859

Data are presented as number of samples, NPX mean, standard deviation (SD) and mean difference (postpartum (pp) - pregnancy (preg)), as well as Linear Mixed model- derived p-values and Bonferroni corrected p-values for the difference between postpartum and pregnancy NPX values.
^*Adjusted for age at partus, pre-pregnancy BMI, antibiotics at blood sampling, and chronic inflammatory or rheumatic disease.

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Table 2 Markers with higher NPX values in pregnancy.

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