Table 5 Microarray studies addressing gene expression profiling of MM-MSC compared to ND-MSC.

From: Transcriptome Analysis of Mesenchymal Stem Cells from Multiple Myeloma Patients Reveals Downregulation of Genes Involved in Cell Cycle Progression, Immune Response, and Bone Metabolism

Casuistic

Comparison design

Microarray

plataform

Number of DEGa/Probesets

Reference

NDb = 7 MMc = 6

MM-MSCd vs. ND-MSCe

GeneChip Human Genome U133 Plus 2.0 Array

183

Corre et al.32

ND = 7 MM = 16

MM-MSC vs. ND-MSC

GeneChip Human Genome U133A Array

79

Todoerti et al.58

ND = 3 MM = 4

MM-MSC vs. ND-MSC

GeneChip Human Genome U133 Plus 2.0 Array

646

André et al.33

ND = 8 MM = 14

(I) [(coMM-MSC¹ vs. MM-MSC - MM-MSC vs. ND-MSC) ∩ (coND-MSC² vs. ND-MSC - MM-MSC vs. ND-MSC)] (II) coMM-MSC vs. MM-MSC exclusive

GeneChip Human Genome U133 Plus 2.0 Array

(I) 2583/

(II) 2553

Garcia-Gomez et al.34

ND = 4 MM = 4

MM-MSC vs. ND-MSC

GeneChip Human Exon 1.0 ST Array

485

Fernando et al.(present study)

  1. aDEG = Differentially Expressed Genes; bND = Normal Donor; cMM = Multiple Myeloma; dMM-MSC = Multiple Myeloma-Mesenchymal Stem Cells; eND-MSC = Normal Donor-Mesenchymal Stem Cells.
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