Figure 2

The change patterns of fall-related (upper panel) and bone-dependent (lower panel) fracture risk factors in late postmenopausal women during 36-month clinical trial. The fall-related fracture risk factors include the number of falls (upper left), the first fall in the time-to-event analysis (upper middle-left), lean mass (upper middle-right) and Timed Up and Go (TUG) score (upper right). The bone-dependent fracture risk factors include femoral neck BMD (lower left), serum osteocalcin levels (lower middle) and urine deoxypyridinoline levels (lower right). The Kaplan–Meier analysis was performed to demonstrate differences in the time to the first fall between two groups. Negative binomial model with log link was used to analyze the number of falls. The Linear model in generalized estimating equations (GEEs) analysis was used to analyze the change patterns over time between two groups. Error bars indicate pointwise 95% confidence intervals for the value of lean mass of left tight, and interquartile ranges for the values of formal neck BMD, TUG, and the levels of osteocalcin and deoxypyridinoline. Note: *P < 0.05 for within-group comparisons in BSYJF group or placebo group in percentage change from baseline. #P < 0.05 for between-group difference at 36 months. BMD = bone mineral density, BSYJF = Bushen Yijing Fang; TUG = Timed Up and Go.