Figure 3 | Scientific Reports

Figure 3

From: PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Figure 3

Mesotrypsin inhibition suppresses invasion and growth of PC9 lung adenocarcinoma cells. (a) Treatment of PC9 cells with mesotrypsin inhibitor diminazene over a range of concentrations (shown below the x-axis of the graph) significantly inhibited PC9 cellular invasion in Matrigel transwell assays. Cells in which PRSS3 expression was silenced by shRNA construct PRSS3-KD1 were evaluated for comparison. Representative images of the invasion assay are shown above each condition. (b) Treatment of PC9 cells with mesotrypsin inhibitor diminazene over a range of concentrations (shown below the x-axis of the plot) significantly inhibited PC9 cell growth as assessed by MTT assays. Cells in which PRSS3 expression was silenced by shRNA construct PRSS3-KD1 were evaluated for comparison. Error bars show SEM. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.

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