Figure 6 | Scientific Reports

Figure 6

From: PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Figure 6

PRSS3 and KLK5 drive expression of highly overlapping gene sets in lung adenocarcinoma cells. (a) Heat map of 2416 genes differentially expressed between NT (control), PRSS3 KD, and KLK5 KD (P < 0.05, FC > 1.5). (b) Overlap of significantly differentially expressed genes (P < 0.05, FC > 1.5; N = 184) between PRSS3 KD vs NT (N = 1345) and KLK5 KD vs NT (N = 1255). (c) Knockdown of PRSS3 or KLK5 significantly decreases expression of WNT6. (d) Knockdown of PRSS3 or KLK5 significantly decreases expression of SNAI3. (e) Knockdown of PRSS3 or KLK5 significantly increases expression of CD83.

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