Table 3 Multivariate Cox proportional hazard models for predictors of overall survival in cohort 1 patients.

From: Digital polymerase chain reaction for detecting c-MYC copy number gain in tissue and cell-free plasma samples of colorectal cancer patients

Factors

Univariate survival analysis

Multivariate survival analysis

HR (95% CI)

P value

HR (95% CI)

P value

c-MYC GCN gain in both SISH and ddPCR (SISH+/ddPCR+)

5.807 (2.072–16.276)

0.001

6.067 (1.912–19.258)

0.002

Venous invasion

5.292 (2.957–9.470)

<0.001

1.476 (0.750–2.904)

NS (0.256)

Differentiation (low grade vs. high grade)

3.619 (1.869–7.008)

<0.001

2.503 (1.212–5.170)

0.013

T stage (1–2 vs. 3–4)

9.051 (1.247–65.675)

0.029

2.395 (0.300–19.139)

NS (0.410)

N stage (0 vs. 1, 2)

5.658 (2.529–12.659)

<0.001

1.770 (0.701–4.469)

NS (0.227)

M stage (0 vs. 1)

14.758 (7.789–27.964)

<0.001

8.882 (4.145–19.031)

<0.001

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