Figure 4
MG132 reversed the high-glucose induced increase of α-SMA. the levels of α-SMA was significantly higher than in CON and were reduced after administration of MG132 and deguelin for the indicted time. α-SMA expression in HMCs was detected by western blotting: HMCs were treated with 5.5 mmol/L (CON) or 30 mmol/L (HG) high glucose for 24 h, 48 h, and 72 h; then, the HG group was treated with MG132 or deguelin. CON: 5.5 mmol/L glucose; HG: 30 mmol/L glucose; MG132: 30 mmol/L glucose with MG132; Deguelin: 30 mmol/L glucose with deguelin; means ± SEM; N = 6; *P < 0.05 vs. CON; #P < 0.05 vs. HG.
