Table 2 Frequency of hepatotoxicity according to severity and onset of antituberculosis drug-induced hepatotoxicity.
From: Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity
N (total = 203) | Proportion | |
|---|---|---|
Severity of hepatotoxicity† | ||
Grade 1 (ALT 2–2.5 times ULN) | 52 | 25.6% |
Grade 2 (ALT 2.5–5 times ULN) | 78 | 38.4% |
Grade 3 (ALT 5–10 times ULN) | 35 | 17.2% |
Grade 4 (ALT > 10 × ULN) | 38 | 18.7% |
Onset of hepatotoxicity after antituberculosis drug usage | ||
<30 days | 104 | 51.2% |
30–60 days | 60 | 29.6% |
60–90 days | 14 | 6.9% |
>90 days | 25 | 12.3% |
