Table 3 Association analysis between the PXR and CAR SNPs and antituberculosis-drug induced hepatotoxicity.

From: Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity

SNP

Genotype†, n case/control

PHWE

Additive*

Dominant*

Recessive*

0/0

0/1

1/1

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

PXR

   rs7643645

70/73

97/150

36/76

0.785

0.704 (0.539–0.918)

0.010

0.609 (0.405–0.917)

0.017

0.645 (0.405–1.026)

0.064

   rs6785049

65/104

107/137

31/58

0.954

0.972 (0.743–1.271)

0.833

1.208 (0.809–1.804)

0.356

0.677 (0.408–1.123)

0.131

   rs3732357

88/131

97/139

18/29

0.143

1.012 (0.756–1.355)

0.936

1.030 (0.706–1.503)

0.878

0.973 (0.510–1.855)

0.934

   rs3814055

117/174

71/107

15/18

0.416

1.112 (0.823–1.502)

0.489

1.068 (0.732–1.559)

0.731

1.473 (0.707–3.066)

0.301

   rs2472682

71/100

102/149

30/50

0.447

0.950 (0.723–1.248)

0.713

1.001 (0.674–1.487)

0.995

0.835 (0.499–1.395)

0.490

   rs3814057

45/74

110/145

48/80

0.716

1.005 (0.770–1.312)

0.970

1.299 (0.831–2.030)

0.251

0.788 (0.509–1.221)

0.286

   rs2472677

82/133

88/142

33/44

0.230

0.968 (0.740–1.266)

0.811

0.891 (0.607–1.306)

0.552

1.097 (0.651–1.847)

0.729

CAR

   rs6686001

136/194

57/98

10/7

0.818

0.991 (0.704–1.395)

0.958

0.912 (0.614–1.354)

0.648

1.766 (0.619–5.034)

0.288

   rs2307424

59/81

94/150

50/68

0.560

0.937 (0.719–1.221)

0.628

0.884 (0.584–1.337)

0.559

0.957 (0.610–1.502)

0.848

   rs4073054

159/243

41/54

3/2

0.815

1.160 (0.752–1.789)

0.502

1.149 (0.723–1.823)

0.556

1.753 (0.243–12.64)

0.578

   rs3003596

59/90

96/147

48/62

0.560

1.032 (0.788–1.351)

0.818

0.997 (0.661–1.504)

0.989

1.104 (0.692–1.763)

0.677

   rs7530560

75/99

89/146

39/54

0.386

0.986 (0.754–1.289)

0.919

0.917 (0.616–1.366)

0.670

1.086 (0.670–1.760)

0.739

   rs2502805

94/129

82/127

27/43

0.066

0.975 (0.743–1.279)

0.855

0.979 (0.668–1.434)

0.913

0.943 (0.547–1.627)

0.833

  1. †“0” represents the major allele, “1” represents the minor allele.
  2. HWE: Hardy-Weinberg equilibrium. HWE was assessed by the χ2 goodness-of-fit test based on the genotype distributions in this study.
  3. *Adjusted for ethnicity, age, gender, height, weight, smoking, drinking, and HbsAg status. Additive: minor allele homozygotes versus heterozygotes versus major allele homozygotes. Dominant: heterozygotes plus minor allele homozygotes versus major allele homozygotes. Recessive: minor allele homozygotes versus major allele homozygotes plus heterozygotes.
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