Table 5 Analyses of derived haplotypes (frequency more than 3%) from six examined polymorphisms of CAR with the risk of ATDH.

From: Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity

Haplotypes†

ATDH group

Non-ATDH group

OR

95% CI

P value

n

%

n

%

H001000

114

28.0

169

28.4

0.946

0.714–1.254

0.699

H011000

47

11.7

57

9.6

1.210

0.804–1.819

0.360

H010011

115

28.2

182

30.5

0.863

0.653–1.141

0.300

H111001

28

6.9

33

5.5

1.239

0.735–2.089

0.421

H000100

76

19.0

107

17.9

1.040

0.751–1.440

0.815

H110011

18

4.5

23

3.9

1.139

0.607–2.135

0.686

  1. †“0” represents the major alleles, “1” represents the minor alleles.
  2. Order of polymorphisms: rs4073054, rs2307424, rs3003596, rs6686001, rs2502805, rs7530560. ATDH: antituberculosis drug-induced hepatotoxicity.
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