Figure 7
HFD-fed aP2-Cre/L-PGDS flox/flox mice exhibited increased insulin sensitivity. (a) Measurement of serum insulin level. Control L-PGDS flox/flox (C: gray columns) and aP2-Cre/L-PGDS flox/flox (LKO: black columns) mice (7-week-old; n = 5) were fed LFD or HFD for 11 weeks. Data are shown as means ± S.D. (b) Insulin tolerance test. Control L-PGDS flox/flox (gray circles; n = 5) and aP2-Cre/L-PGDS flox/flox (black circles; n = 5) mice (7-week-old) were fed LFD or HFD for 11 weeks, and fasted for 16 h before receiving an i.p. injection of 0.75 U/kg insulin. Serum glucose concentrations were measured at indicated time points. Data are shown as means ± S.D. The area under the curve (AUC) was compared by student’s t-test. #p < 0.01, as compared with the HFD-fed L-PGDS flox/flox mice.
