Table 5 Predicted QTL effects and potential genetic improvement from marker-assisted selection (MAS) for traits GNL, OS-C, 3′-SL and OS-B.

From: Fine-mapping sequence mutations with a major effect on oligosaccharide content in bovine milk

Chromosome: Position

OS

MAFa

in this study

(N = 332)

MAF

in general Holstein population

(N = 37678)

Effect size (arbitrary unit)

Current genetic average in populationb

Potential genetic average from MASc

Potential genetic improvement (fold) from MASd

Chr11:

104229609

GNL

0.35

0.39

4724310

3684962

9448620

2.6

Chr11:

104229609

OS-C

0.35

0.39

247826

193304

495652

2.6

Chr1:

42593589

3′-SL

0.23

0.22

1062120

467333

2124240

4.5

Chr16:

53653341

OS-B

0.12

0.16

103766

33205

207532

6.3

Chr10:

6491671

OS-B

0.42

0.55

62639

68903

125278

1.8

Chr26:

36764962

OS-B

0.06

0.06

132046

15846

264092

16.7

  1. aMAF: Minor Allele Frequency.
  2. bGenetic average based on the marker effect and Hardy-Weinberg equilibrium genotype frequencies in the general Holstein population.
  3. cPotential average based on selection for the entire herd carrying only the favourable alleles.
  4. dDifference between the current genetic average due to the favourable mutation and the potential genetic average if all animals were selected to carry 2 copies of the favourable alleles.
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