Figure 7

Abundance of genes involved in the biosynthesis of unsaturated fatty acids are depleted in SERT^−/− mice and are associated with the expression of HMGCS2 and HMGCR. (A) Abundance (log₁₀ normalized count) of the KEGG pathway, biosynthesis of unsaturated fatty acids [ko01040]. Differential abundance testing was performed by likelihood ratio test (DESeq. 2), adjusted p < 0.1 (Benjamini-Hochberg multiple testing correction) was considered significant. (B) Linear regression between gene expression of HMGCS2 (ΔCt) and abundance of the KEGG pathway, biosynthesis of unsaturated fatty acids [ko01040], p < 0.05 was considered significant. Points are colored by SERT^+/+ and SERT^−/− mice.