Figure 5 | Scientific Reports

Figure 5

From: Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Figure 5

Design of the CP OCT study: (а) the study was performed on material from operative biopsies as follows: 30 patients with gliomas of different grades of malignancy; in total, 123 ex vivo specimens were analyzed; (b) MRI image of astrocytoma grade II (left) and glioblastoma grade IV (right) with outlining trajectory of surgical approach (orange dotted lines) and the areas of tissue sampling: area within the yellow dotted line — center of the tumor; area within green dotted line — peritumoral area; area within blue dotted line — edge of the resection (nontumorous tissue at the place of access to the tumor); (c) enlarged part of monitor with B-scans and en face OCT images in co- and cross-polarization; (d) working area for CP OCT scanning with the CP OCT device and on-mount optical probe; (e) resected specimen with schematic markings of the scanning area along the central line (yellow dotted line); (f) position of contactless forward-looking optic fiber CP OCT probe above the sample.

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