Table 3 List of the selected miRNAs associated with skeletal muscle and bone with known functions in human.

hsa-let-7a-5p

n.d.

Muscle atrophy

¹⁸

hsa-miR-1

HDAC4, CX43, MyoD, Pax7

Skeletal muscle development and differentiation

^{31, 32}

n.d.

Adaptive response to PA

^{20,21,– 22}

hsa-miR-101-3p

n.d.

Muscle atrophy

¹⁸

EZH2

Promotion of hMSCs differentiation

⁴⁴

hsa-miR-103a-3p

n.d.

Myogenesis

¹⁷

RUNX2

Inhibition of osteoblast differentiation

⁴⁵

hsa-miR-107

n.d.

Myogenesis

¹⁷

hsa-miR-125b-5p

Osx

Inhibition of hMSCs proliferation and differentiation

⁴⁶

BMPR1b

Inhibition of hMSCs differentiation

⁴⁷

n.d.

Bone mineral density (Osteoporosis)

⁴⁸

hsa-miR-140-5p

BMP-2

Inhibition of the osteogenic lineage commitment in undifferentiated hMSCs

⁴⁹

hsa-miR-142-3p

PKCα

Reduction of osteoclast viability

⁵⁴

APC

Promotion of osteoblast differentiation trough WNT signaling

⁵⁰

hsa-miR-148b-3p

n.d.

Muscle atrophy

¹⁸

hsa-miR-181a-5p

n.d.

Adaptive response to PA

²²

hsa-miR-28-3p

n.d.

Myogenesis

¹⁷

hsa-miR-199a-5p

FDZ, JAG1, WNT2

Maintenance of muscle satellite cells and differentiation of satellite cells into myofibers

³⁴

LIF

Promotion of hMSCs differentiation

⁵¹

hsa-miR-29a

DKK1, Kremen2, sFRP2

Promotion of osteoblasts differentiation

⁵²

n.d.

Adaptive response to PA

²¹

hsa-miR-29 b/c

YY1

Promotion of skeletal muscle differentiation

³³

TRAcP, MMP9, c-FOS, NAFTc-1

Inhibition of osteoclast differentiation

⁵⁵

n.d.

Adaptive response to PA

²²

hsa-miR-324-5p

n.d.

Myogenesis

¹⁷

hsa-miR-331-3p

n.d.

Myogenesis

¹⁷

hsa-miR-335-5p

RUNX2

Inhibition of hMSCs proliferation, migration and differentiation

⁵³

hsa-miR-374a-5p

n.d.

Myogenesis

¹⁷

hsa-miR-378a-5p

n.d.

Adaptive response to PA

²¹

hsa-miR-424-5p

PolR1A, RRN3, UBTF

Muscle wasting

¹⁹

hsa-miR-502-3p

n.d.

Myogenesis

¹⁷

hsa-miR-660-5p

n.d.

Myogenesis

¹⁷