Figure 5 | Scientific Reports

Figure 5

From: The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association

Figure 5

The density of positive cells for CD8+, STAT3 and Phospho-STAT3 in experimental groups. (A) CD8+: *p = 0.006 compared to Control/SAL. Control/SAL n = 9, Control/LPS n = 9, CS/SAL n = 8, CS/LPS n = 5. Photomicrographs of CD8 T cells in lung parenchyma (B) Control/SAL group; (C) Control/LPS group; (D) CS/SAL group and (E) CS/LPS group, 400X magnification. (F) STAT3: *p < 0.001 compared to Control/SAL; **p < 0.001 compared to CS/SAL group and ***p < 0.001 compared to Control/LPS group. Control/SAL n = 7, Control/LPS n = 9, CS/SAL n = 6, CS/LPS n = 5. Photomicrographs of STAT3 in lung parenchyma (G) Control/SAL group; (H) Control/LPS group; (I) CS/SAL group and (J) CS/LPS group, 400X magnification. Data were expressed as log10 base. ANOVA, Holm-Sidak post hoc. Data are presented as means and SE. (K) Phospho-STAT3: *p < 0.001 compared to Control/SAL. Control/SAL n = 8, Control/LPS n = 8, CS/SAL n = 8, CS/LPS n = 4. Photomicrographs of Phospho-STAT3 in lung parenchyma (L) Control/SAL group; (M) Control/LPS group; (N) CS/SAL group and (O) CS/LPS group, 400X magnification. Data were expressed as log10 base. Kruskal-Wallis, Dunn’s post hoc. Data are presented as means and SE.

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