Figure 1
From: Metabolic adaptation of adherent-invasive Escherichia coli to exposure to bile salts
Bile salts induce a global up-regulation of LF82 genes involved in degradation pathways and a down-regulation of those implicated in biosynthetic pathways. Gene expression from AIEC strain LF82 after growth in either mM9 minimal medium or mM9 supplemented with bile salts. The proportion of up- and downregulated genes (upon bile salts exposure relative to control) in major biological pathways of metabolism was compared to those in the whole transcriptome background using a hypergeometric test. A p value ≤ 0.05 was considered as significant. (A) Distribution of the upregulated and the downregulated genes in the different metabolic pathways. The percentage of LF82 genes involved in every metabolic pathway is indicated in pie chart. The percentage of increased transcript levels and of decreased transcript levels in every pathway are represented on the right: 62% genes encoding proteins involved in the degradation, utilization and assimilation of compounds were up-regulated (p < 0,001) and 83% genes involved in biosynthesis pathways were down-regulated (p < 0,001) in the presence of bile salts. (B) Distribution of the upregulated genes in main degradation pathways. The percentage of LF82 genes involved in each pathway is indicated in pie chart. The percentage of increased transcript levels in every degradation pathways are presented on the right.
