Figure 11

Purification and identity of the major components in PTI-777. (a) Structure of fraction f as chlorogenic acid (b) Structure of fraction j as epicatechin. (c) Structure of fraction h2 as epicatechin-4β-8-epicatechin (known as proanthocyanidin B2). (d) Structure of fraction h1 as catechin-4α-8-epicatechin (known as proanthocyanidin B4). (e) Structure of fraction k2 as epicatechin-4β-8-epicatechin-4β-8-epicatechin (known as proanthocyanidin C1). (f) Structure of fraction k1 as epiafzelechin-4β-8-epicatechin. See Supplement Results and Figures for structural elucidation and identification studies.