Figure 12 | Scientific Reports

Figure 12

From: The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

Figure 12

PTI-00703 cat’s claw proanthocyanidins are potent disrupters of Aβ 1–42 fibrils. (a) Disruption/disassembly of Aβ 1–42 fibrils by specific PTI-00703 cat’s claw proanthocyanidins. Compound h2 (epicatechin-4β → 8-epicatechin; proanthocyanidin B2) caused a dose-dependent disruption/disaggregation of pre-formed Aβ 1–42 fibrils. Similarly, compound f (chlorogenic acid), compound k1 (epicatechin trimer; proanthocyanidin C1) and compound k2 (epifzeledin-4β-8-epicatechin) all caused a marked disruption/reduction of preformed Aβ 1–42 fibrils when used at a 1:1 wt/wt ratio. The major cat’s claw alkaloid mitraphylline was found to be totally ineffective. **p < 0.01, ***p < 0.001, by Student’s t-test. Bars represent mean +/− SEM. n = 5. (b,c) Disruption/disaggregation of pre-formed Aβ 1–42 and 1–40 fibrils by epicatechin-4β-8-epicatechin (i.e. proanthocyanidin B2; compound h2) as assessed by CD spectroscopy.

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