Figure 6 | Scientific Reports

Figure 6

From: The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

Figure 6

PTI-777 profile (major Aβ inhibitory ingredients in PTI-00703 cat’s claw). (a) Preparative HPLC Profile of PTI-777 that demonstrated the major water-soluble Aβ inhibitory components isolated from Uncaria tomentosa (cat’s claw), noted (from left to right) as Fractions g, f, h, i, j, k1, k2, l, m/n and o. (b) Identification of each fraction using a variety of techniques including PTI-00703 cat’s claw, PTI-777, and individual fractions of PTI-777 were assessed by Thioflavin T fluorometry. PTI-00703 cat’s claw, PTI-777, and individual fractions f-n were all significant effective disrupters/reducers of Aβ 1–42 fibrils. On the other hand, the cat’s claw alkaloids isopteropodine, pteropodine, isomatraphyline and mitraphylline had no significant effects on disaggregation/reduction of pre-formed Aβ 1–42 fibrils. Bars represent mean +/− SEM. n = 5.

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