Figure 1
From: A genome-wide enhancer/suppressor screen for Dube3a interacting genes in Drosophila melanogaster
Identification of enhancers of the rough eye phenotype generated by Dube3a overexpression with GMR-GAL4. The first column represents control fly eyes, indicating the mild rough eye phenotype generated with GMR > Dube3a45 (A) and the severe rough eye phenotype with GMR > Dube3a27 (E). Columns 2–4 are representative images of eyes of the enhancement observed with GABA-B-R3-RNAi (B,F), IA2-RNAi (C,G), and lola-RNAi (D,H), respectively. Note the increase in necrosis observed in the RNAi lines crossed to GMR > Dube3a27 (E–H). No rough eye phenotypes were observed with the GMR > TRiP-Control line or any uas-RNAi line alone (I–L).
