Figure 5 | Scientific Reports

Figure 5

From: Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

Figure 5

Y27pPBHSA improves renal hemodynamics in cirrhotic rats. Renal rock2 and pdgfrb mRNA expression. (A) Western blots for p-moesin/moesin, p-MLC/MLC and GAPDH. (B) col1a1 and acta2 mRNA expression. (C) Renal arterial flow in ml/min/kidney (D) and ngal mRNA expression (E) in kidney from Y27pPBHSA-treated BDL or CCl4 cirrhotic rats. Results are expressed as mean ± standard error of the mean (SEM); n = 6/group, *p < 0.05, **p < 0.01 and ***p < 0.001 for BDL or CCl4 cirrhotic rats vs. corresponding control rats; •p < 0.05 for Y27pPBHSA-treated vs. non-treated cirrhotic rats. Abbreviations: p-MLC, phospho-myosin light chain; BDL, bile duct ligation: Ngal, neutrophil gelatinase-associated lipocalin.

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