Figure 3
From: Knockout rat models mimicking human atherosclerosis created by Cpf1-mediated gene targeting
Different immune cell distribution between Apoe knockout rats and mice in partially ligated carotid artery. Apoe-deficient animals with 8 to 10 week-old age were undergone partial ligation of left carotid artery and subsequently fed with HFD for 2 weeks. (A) CD19-, CD3-, and CD68-positive cells in partially ligated carotid artery from Apoe knockout rats and mice. Arrowheads indicate positive cells in media (yellow) or adventitia (red). Scale bar, 50 μm. (B) Adventitial macrophage progenitor cells (AMPCs) in arteries of Apoe knockout rats and mice. Red arrowheads indicate CD45+Sca1+ cells. RCA, un-ligated right carotid artery; LCA, left partially ligated carotid artery; M, media; A, adventitia. Scale bar, 50 μm.
