Figure 4
From: Three distinct regions of cRaf kinase domain interact with membrane
Peptide-lipid interactions in cRaf (A) and mTOR. (B) The helices in both cRaf αC-Pept and mTORFRB-pept are amphipathic (left). Average probability of contact between protein and lipids (middle). Contact is defined when any protein heavy atoms is within 4Å of heavy atoms of lipid headgroups. A snapshot showing residues in contact with membrane for >50% of the simulation length (right). Color scheme: (left)-charged surface (blue transparent ovals), basic residues (blue), acidic residues (red), hydrophobic (white), others (green); (right)-helical region (orange), carbon (yellow), residues in contact with membrane are highlighted by blue points. The membrane is shown in gray sticks.
