Figure 6
From: Three distinct regions of cRaf kinase domain interact with membrane
(A) Last snapshot of cRaf kinase domain (orange ribbons) bound to the PA/PC membrane (blue surface) from the simulation \(cRa{f}_{tk-CAAX}^{KinaseD}\). Only the kinase domain is shown. Water is shown as green dots. αC-helix from the N-lobe of cRaf kinase domain is labeled. (B) Probability of the residue contact with the lipids in cRaf KinaseD plus \(cRa{f}_{tk-CAAX}^{KinaseD}\). Cutoff criteria are same as in Fig. 4. Three regions are in direct contact with membrane phospholipids, N-terminal acidic region (NtA, yellow); the basic cluster (blue); and the activation segment (AS, green). (C) A snapshot from the \(cRa{f}_{tk-CAAX}^{KinaseD}\) simulation with membrane-interacting residues shown as sticks (C: green, N: blue; O: red). Protein is in orange and membrane in white surface representation. An extended membrane-interacting sequence code is highlighted in the brown box.
