Figure 8
From: Three distinct regions of cRaf kinase domain interact with membrane
An illustration showing similarities between KRAS and cRaf. Both contain hostpot regions, helix 3 (H3) and helix 4 (H4) in KRAS and RKTR motif in cRaf kinase domain (cRaf:KinaseD). In both, the hotspot interacts with the membrane when they are monomers. Both undergo dimerization with their hotspot regions lying at the dimer interface.
