Figure 2 | Scientific Reports

Figure 2

From: Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model

Figure 2

No effect of allopregnanolone (ALLO) on pruritogen-induced scratching in normal mice. Vehicle (saline) or ALLO (10 mg/kg, i.p.) was administered to normal mice, and 10 min later, saline (50 µL/site), histamine (Hist, 250 µg/50 µL/site) or chloroquine (CQ, 200 µg/50 µL/site) was i.d. injected to the nape of the neck. Immediately after i.d. injection, the number of scratching bouts on the injection site was measured for 1 h. Each column represents the mean ± S.E.M. of four animals. *P < 0.05, one-way ANOVA with Bonferroni’s multiple comparison test.

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