Figure 6
Suppression of ethanol-induced scratching and brain allopregnanolone (ALLO) production in atopic dermatitis-induced mice pre-treated with the 5α-reductase inhibitor, finasteride. (a,b) Vehicle (20% β-cyclodextrin-containing saline) or finasteride (FIN, 50 mg/kg, i.p.) was twice administered 24 h and 1 h before administration of ethanol (2.4 g/kg, p.o.). (a) Cumulative duration of scratching during 1 h period after ethanol administration. (b) Brain ALLO levels 10 min after ethanol administration. Each column represents mean ± S.E.M. of (a) 16 or 17 and (b) four or five animals. *P < 0.05 and **P < 0.01, vs. vehicle (Veh), unpaired Student’s t-test.
