Figure 4
Effect of imiquimod on the oxidative burst in mice infected with Hk x-31 IAV. Oxidative burst measured by L-012 enhanced chemiluminescence in naïve mice (control; PBS) or mice infected with Hk x-31 at 105 PFU/mouse with daily intranasal treatments of either imiquimod (50 µg) or vehicle control (PBS: DMSO; 1%), starting 1 day prior to infection up until day 2 with analysis occurring at day 3. Data are represented as mean ± SEM of n = 8–15 mice. Data are expressed as relative light units (RLU), measured as an average of triplicates over a 60-cycle period, subtracted by blank readings. Statistical analysis was conducted via a one-way ANOVA followed by Tukey’s post hoc test for multiple comparisons. ** indicates p < 0.01.
