Figure 1

Pc and Ps probands and their parental affiliation. Pc, (Proband crude, number of patients observed: total (males, females)). Ps, (Proband standard, number of patients according to monoparental affiliation). Arrow shows the conversion of Pc to Ps. PA and MA, patrilineal and matrilineal; PA = MA, mixed or uncertain parental affiliation; Other vertical pairs than Parent-Offspring, for example, Proband-Uncle, Proband-Aunt pairs. A given Pc can act in several combinations of pairs at the same time, for example in sib concordance and concomitantly in a Parent-Offspring pair. Therefore, the number of pairs is not half the number of patients. Abbreviations, diagnoses (cf. Table 1): LPD, lymphoproliferative disorders; Other LPD, T-NHL, Burkitt-NHL, WA, PLL and HCL; MPD, myeloproliferative disorders; Other MPD, PV, MDS, ML NOS.