Figure 2 | Scientific Reports

Figure 2

From: Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity

Figure 2

Increased sensitivity in A-T airway epithelial cells to S. pneumoniae infection. (A) Percentage of cell death induced by S. pneumoniae infection in control and A-T cells in the presence or absence of catalase (cat). Unpaired, two-tailed Mann-Whitney tests were carried out. *p < 0.03 between control and A-T at 8 h, and A-T and A-T + cat at 8 h. (B,C) Increase in inflammasome-independent pro-inflammatory cytokines IL-8 and TNF-α respectively in A-T as compared to control cells. Co-culture with catalase (cat) decreased this response. (D) Decrease in inflammasome-dependent cytokine IL-1β in A-T as compared to control cells, suggesting a defect in inflammasome activation. A-T n = 7, healthy controls n = 7. All data were plotted as the mean ± s.d. Kruskal-Wallis tests were performed and when significant (p < 0.05), Mann-Whitney tests were carried out. ns; not significant, *p < 0.03.

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