Figure 4 | Scientific Reports

Figure 4

From: Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity

Figure 4

Increase in pro-inflammatory cytokines in A-T ALI cultures post-infection. (A,B) Increase in inflammasome-independent pro-inflammatory cytokines IL-8 and TNF-α in A-T as compared to control cells respectively. (C) Decrease in inflammasome-dependent cytokine IL-1β in A-T as compared to control cells, suggesting a defect in inflammasome activation. A-T n = 3, healthy controls n = 3. All data were plotted as the mean ± s.d. Unpaired, two-tailed Mann-Whitney tests were carried out. ns; not significant, *p < 0.03.

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