Table 2 Effect size and significance of correlations between psychiatric PRS and deep grey matter volumes for the full mixed-ancestral cohort. Standardised beta co-efficients and raw P-values are quoted. Raw P-values < 0.05 are shown in bold. Results surviving multiple-correction testing (p < 0.0083) are indicated with an asterisk (*).

Psychiatric genetic risk scores: SNPs with P-values <		Caudate Nucleus Volume	Thalamic Volume	Subthalamic Nucleus Volume	Lentiform Nucleus Volume
0.5	R²	0.007009	0.000452	0.001693	0.01871
	β	−0.08	0.02	−0.04	−0.14
	P-value	0.25	0.77	0.57	0.06
0.1	R²	0.01342	0.004909	0.02266	0.0567
	β	−0.12	−0.07	−0.15	−0.24
	P-value	0.11	0.33	0.04	0.0008*
0.05	R²	0.01417	0.004607	0.03233	0.04602
	β	−0.12	−0.07	−0.18	−0.21
	P-value	0.10	0.34	0.01	0.0027*
0.01	R²	0.005814	0.001811	0.02966	0.02327
	β	−0.08	−0.04	−0.17	−0.15
	P-value	0.29	0.56	0.02	0.03
0.001	R²	0.0106	0.000523	0.004517	0.005528
	β	−0.10	−0.02	−0.06	−0.07
	P-value	0.15	0.75	0.35	0.30

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