Table 2 Results of mediation analysis: direct, indirect and total effects of NLR on CVEs mediated by diabetes mellitus, creatinine, and hypertension via pathway A.

From: Mediation Effect of Neutrophil Lymphocyte Ratio on Cardiometabolic Risk Factors and Cardiovascular Events

Path

Effect

SE

z

P-value

Bootstrapping

Odds Ratio

95% CI

Proportion mediated (%)

Bias Corrected 95%CI

Direct effect

0.2246

0.0535

4.20

<0.001

0.1235, 0.3306

1.2518

1.1315, 1.3918

44.73

Indirect effects

  Overall

0.2775

0.1344

2.06

0.039

0.0505, 0.5864

1.3198

1.0141, 1.7176

55.27

  Through DM

0.1030

0.0402

2.56

0.010

0.0423, 0.2127

1.1085

1.0199, 1.1971

20.51

  Through Cr

0.0248

0.0083

3.00

0.003

0.0111, 0.0443

1.0251

1.0084, 1.0418

4.94

  Through HT1

0.0400

0.0759

0.53

0.598

−0.1144, 0.1842

1.0409

0.8849, 1.1968

7.97

  Through HT2

0.1097

0.0427

2.56

0.010

0.0438, 0.2122

1.1159

1.0209, 1.2108

21.85

One mediator model

  NLR→DM→CVEs

0.0564

0.0250

2.25

0.024

0.0203, 0.1209

1.0580

1.0058, 1.1102

11.23

  NLR→ Cr →CVEs

0.0138

0.0041

3.37

0.001

0.0060, 0.0219

1.0139

1.0058, 1.0220

2.75

  NLR→HT1→CVEs

0.0315

0.0605

0.52

0.602

−0.0886, 0.1478

1.0320

0.9089, 1.1551

6.27

  NLR→ HT2→CVEs

0.0681

0.0306

2.23

0.026

0.0227, 0.1477

1.0705

1.0054, 1.1355

13.56

Two mediators model

  NLR→DM→Cr → CVEs

0.0031

0.0014

2.19

0.028

0.0012, 0.0069

1.0031

1.0003, 1.0058

0.62

  NLR→DM→HT1→CVEs

0.0072

0.0142

0.51

0.612

−0.0180, 0.0397

1.0072

0.9791, 1.0354

1.43

  NLR→DM→HT2→CVEs

0.0349

0.0161

2.16

0.031

0.0129, 0.0791

1.0355

1.0025, 1.0685

6.95

  NLR→Cr→HT1→CVEs

0.0011

0.0023

0.45

0.649

−0.0027, 0.0076

1.0011

0.9965, 1.0056

0.22

  NLR→Cr→HT2 →CVEs

0.0054

0.0033

1.66

0.097

0.0015, 0.0151

1.0054

0.9989, 1.0119

1.08

Three mediators model

  NLR→DM→Cr→HT1 →CVEs

0.0002

0.0005

0.46

0.646

−0.0006, 0.0016

1.0002

0.9992, 1.0012

0.04

  NLR→DM→Cr→HT2 →CVEs

0.0012

0.0007

1.64

0.101

0.0004, 0.0035

1.0012

0.9998, 1.0027

0.24

Total effect

0.5021

0.1388

3.62

<0.001

0.2480, 0.7941

1.6522

0.2301, 0.7741

100

  1. CI, confidence interval; NLR, neutrophil-lymphocyte ratio; CVEs, cardiovascular events; DM, diabetes mellitus; Cr, creatinine; HT1, well-controlled hypertension; HT2, poorly-controlled hypertension.
Back to article page