Table 3 Multivariable logistic regression analysis for occurrence of postoperative acute kidney injury after laparoscopic major abdominal surgery in total patients.

From: Retrospective analysis of the association between intraoperative magnesium sulfate infusion and postoperative acute kidney injury after major laparoscopic abdominal surgery

Variables

Multivariable model

Odds ratio (95% CI)

P-value

Sex: male (vs female)

1.47 (1.02, 2.11)

0.038

Age, yr

1.01 (0.99, 1.022)

0.242

Body mass index, kg m−2

0.98 (0.94, 1.03)

0.408

Preoperative ASA physical status

1

1

(<0.001)

2

1.73 (1.09, 2.73)

0.019

3 + 4

4.20 (2.18, 8.10)

<0.001

Preoperative eGFRa, mL min−1 1.73 m−2

≥90

1

 

<90

0.49 (0.35, 0.71)

<0.001

Surgery time, min

1.00 (1.00, 1.01)

<0.001

Intraoperative magnesium sulfate use

0.37 (0.14, 0.94)

0.037

Staff anesthesiologist A (vs other anesthesiologists)

0.68 (0.31, 1.50)

0.340

Diagnosis of cancer

0.43 (0.30, 0.63)

<0.001

Hypertension

1.15 (0.79, 1.67)

0.476

Ischemic heart disease

1.17 (0.66, 2.07)

0.586

Cerebrovascular disease

0.99 (0.46, 2.14)

0.984

Potential risk of postoperative AKI on POD 0-3

  Intraoperative vasopressor infusion

4.19 (2.15, 8.16)

<0.001

  Antibiotics or Antiviral drug use

2.18 (1.31, 3.63)

0.003

  Radiocontrast use

1.83 (1.03, 3.27)

0.041

  Hydroxyethyl starch use

1.79 (1.24, 2.58)

0.002

  Exposure of anemia (hemoglobin <10 g dL−1)

2.00 (1.30, 3.07)

0.002

Year of surgery

2010–2012

1

(0.006)

2013–2014

0.65 (0.42, 1.00)

0.049

2015–2016

0.54 (0.36, 0.80)

0.002

  1. Covariates of P < 0.1 in bold font were included in final multivariable logistic regression model.
  2. Hosmer-Lemeshow statistics (Chi-square: 3.65, df: 8, P = 0.888).
  3. Preoperative eGFRa (mL min−1 1.73 m−2): 186 × (Creatinine)−1.154 × (Age)−0.203 × (0.742 if female).
  4. Antibiotics or antiviral drugb includes vancomycin, cephalosporin, aminoglycoside, Rifampin, Acyclovir, and sulfonamide.
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