Table 1 Tissue weights in postnatal day (P) 14 and P45 male mice.

From: Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice

Tissue/Measure

Control

Early Overnutrition

p-value

P14

   nasoanal length (cm)

6.6 (6.5–6.7)

7.0 (6.9–7.1)

**<0.001

   eWAT (mg/g bw)

2.345 (2.090–3.033)

5.388 (3.703–8.159)

**<0.001

   rpWAT (g)

0.014 (0.010–0.017)

0.033 (0.026–0.044)

**<0.001

   rpWAT (mg/g bw)

1.379 (0.918–1.643)

2.580 (2.024–3.320)

**<0.001

   mWAT (g)

0.045 (0.042–0.056)

0.074 (0.065–0.081)

**<0.001

   mWAT (mg/g bw)

4.740 (4.080–5.170)

5.866 (5.014–6.152)

*0.011

   pancreas (g)

0.022 (0.020–0.025)

0.029 (0.027–0.033)

*0.001

   pancreas (mg/g bw)

2.110 (2.032–2.428)

2.220 (2.066–2.413)

0.707

   liver (g)

0.399 (0.360–0.442)

0.557 (0.544–0.582)

**<0.001

   liver (g/g bw)

0.038 (0.037–0.042)

0.043 (0.041–0.044)

*0.016

   kidney (g)

0.068 (0.066–0.072)

0.088 (0.083–0.091)

**<0.001

   kidney (mg/g bw)

6.541 (6.323–7.455)

6.584 (6.349–7.125)

0.689

   spleen (g)

0.056 (0.049–0.063)

0.078 (0.065–0.104)

**<0.001

   spleen (mg/g bw)

5.365 (4.714–6.108)

6.043 (5.138–7.998)

0.110

P45

   nasoanal length (cm)

10.3 (10.0–10.8)

10.5 (10.2–10.6)

0.796

   eWAT (g)

0.559 (0.386–0.750)

1.019 (0.816–1.052)

*0.008

   eWAT (mg/g bw)

14.66 (10.47–19.34)

22.03 (19.06–22.90)

*0.039

   rpWAT (g)

0.184 (0.076–0.211)

0.206 (0.164–0.281)

0.199

   mWAT (g)

0.372 (0.256–0.461)

0.598 (0.355–0.847)

0.091

   pancreas (g)

0.364 (0.300–0.397)

0.395 (0.350–0.409)

0.272

   liver (g)

1.693 (1.634–1.989)

2.101 (1.898–2.200)

0.061

   kidney (g)

0.352 (0.308–0.387)

0.412 (0.394–0.423)

*0.014

kidney (mg/g bw)

9.395 (8.425–9.897)

9.258 (8.697–9.551)

0.908

   spleen (g)

0.164 (0.122–0.181)

0.161 (0.131–0.172)

0.981

  1. Values represent median (interquartile range), n = 11–13 per group at P14 and n = 5 per group at P45. P14 spleen (g and mg/g bw) and P14 and P45 kidney (mg/g bw) weights analyzed by Mann-Whitney, all others by unpaired t-test. eWAT: epididymal white adipose tissue; rpWAT: retroperitoneal white adipose tissue; mWAT: mesenteric white adipose tissue; bw: body weight. *p < 0.05, **p < 0.001.