Table 2 Identification of potent P. a. ATCC 10145-cidal HRNR2591–2684 peptide fragments.

From: Cationic Intrinsically Disordered Antimicrobial Peptides (CIDAMPs) Represent a New Paradigm of Innate Defense with a Potential for Novel Anti-Infectives

AA-sequence

Net charge*

Name

n

LD90 (µg/ml)

LD100 (µg/ml)

HGSRSGQSSRGERHGSSSGSSSH

+5

HR 1-11, HRNR2606–2628

2

0.075

2.35

GRHGSGLGHSSSHGQHGSGSGRSSSRGPY

+7

HR 1-17, HRNR2656–2684

2

0.038

0.15

GRHGSGLGHSSSHGQHGSGSGR

+6

HR 1-18, HRNR2656–2677

7

0.038

0.15

  1. Test condition: 10 mM NaP, pH 5.5 and 0.25% glucose. *At pH 5.5. The results shown are representatives. n: number of experiments.
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