Table 6 Ultrashort palmitoylated Gly-rich CIDAMPs, containing structurally different cationic AA, are bactericidal for S. aureus ATCC 6538.
AA-sequence | Name | n | LD100 (µg/mL) | LD90 (µg/mL) | Condition |
|---|---|---|---|---|---|
Pal-GHHGGHGGHGHGH | Pal-GH13 | 2 | 300 | 0.3 | pH5.5, 0.25% glucose |
Pal-GHHGGHGGHGHGH | Pal-GH13 | 1 | >300 | 0.3 | pH7.0, 0.25% glucose |
Pal-GRRGGRGGRGRGR | Pal-GR13 | 1 | 4.7 | 0.3 | pH5.5, 1% TSB |
Pal-GRRGGRGGRGRGR | Pal-GR13 | 2 | 0.3 | 0.075 | pH5.5, 0.25% glucose |
Pal-GRDRDGGRDGGRDGRDGRD | (D)-Pal-GR13 | 2 | 75, LD99: 0.59 | 0.075 | pH5.5, 0.25% glucose |
Pal-GKKGGKGGKGKGK | Pal-K-GR13 | 2 | >300 | 0.59 | pH5.5, 0.25% glucose |
Pal-GOOGGOGGOGOGO | Pal-Orn-GR13 | 2 | 18.75 | 0.15 | pH5.5, 0.25% glucose |
Pal-GRRGGRGGRGR | Pal-GR11 | 1 | 75,LD99: 1.18 | 0.3 | pH7.3, 1% TSB |
Pal-GRRGGRGGR | Pal-GR9 | 1 | 300, LD99: 4.7 | 1.18 | pH5.5, 0.25% glucose |
Pal-GRDRDGGRDGGRD | (D)-Pal-GR9 | 1 | 2.35 | 0.15 | pH5.5, 0.25% glucose |
Pal-GRRGGR | Pal-GR6 | 2 | 37.5, LD99: 4.7 | 2.35 | pH5.5, 0.25% glucose |
Pal-GRGR | Pal-GR4 | 2 | 9.375, LD99: 4.7 | 2.35 | pH5.5, 0.25% glucose |
Pal-GRDGRD | Pal-(D)-GR4 | 1 | 37.5 | 18.75 | pH5.5, 0.25% glucose |
Pal-GKGK | Pal-GK4 | 2 | 9.375 | 4.7 | pH5.5, 0.25% glucose |
Pal-GKDGKD | Pal-(D)-GK4 | 1 | 9.375 | 4.7 | pH5.5, 0.25% glucose |
Pal-GOGO | Pal-GO4 | 1 | 37. 5 | 9.38 | pH5.5, 0.25% glucose |
Pal-GODGOD | Pal-(D)-GO4 | 1 | 18.75 | 9.38 | pH5.5, 0.25% glucose |
Pal-GlyDabGlyDab | Pal-G-Dab4 | 2 | 18.75 | 4.7 | pH5.5, 0.25% glucose |
Pal-GlyDapGlyDap | Pal-G-Dap4 | 2 | 4.7 | 2.35 | pH5.5, 0.25% glucose |
