Table 7 Antimicrobial activity spectrum of Pal-GR13*.

From: Cationic Intrinsically Disordered Antimicrobial Peptides (CIDAMPs) Represent a New Paradigm of Innate Defense with a Potential for Novel Anti-Infectives

Microorganism

n

LD100 (µg/mL)

LD90 (µg/mL)

Conditions

Burkholderia cepacia ATCC 25416

2

18.75

18.75

pH 7.3, 1% TSB

Burkholderia cepacia ATCC 25416

3

9.375

4.7

pH 7.3, 0.25% glucose

Burkholderia cepacia ATCC 25416

2

>300

>300

pH 5.5, 0.25% glucose

Escherichia coli ATCC 11775

1

2.35

1.18

pH 7.3, 1% TSB

Escherichia coli ATCC 11775

2

0.59

0.15

pH 5.5, 0.25% glucose

Klebsiella pneumoniae ATCC 13883

1

1.18

1.18

pH 7.3, 1% TSB

Klebsiella pneumoniae ATCC 13883

2

0.3

0.15

pH 5.5, 0.25% glucose

Moraxella osloensis RV A2/2001

1

4.7

0.59

pH 7.3, 1% TSB

Prevotella oralis ATCC 33321

1

18.75

9.38

pH 7.3, 1% TSB

Pseudomonas aeruginosa ATCC 10145

2

1.18

0.3

pH 7.3, 1% TSB

Pseudomonas aeruginosa ATCC10145

2

0.3

0.075

pH 5.5, 0.25% glucose

Salmonella typhimurium ATCC 13311

2

2.35

2.35

pH 7.3, 1% TSB

Clostridium perfringens ATCC 13124

1

37.5

18.75

pH 7.3, 1% TSB

Clostridium perfringens ATCC 13124

1

18.75

4.7

pH 7.3, 0.25% glucose

Clostridium perfringens ATCC 13124

1

75

37.5

pH 5.5, 0.25% glucose

Corynebacterium simulans DSM 44415

1

2.35

0.59

pH 7.3, 1% TSB

Lactobacillus crispatus DSM 20584

2

75

9.38

pH 7.3, 1% TSB

Peptostreptococcus magnus ATCC 15794**

2

37.5

4.7

pH 7.3, 1% TSB

Propionibacterium acnes ATCC 6919

1

4.7

1.18

pH 7.3, 1% TSB

Propionibacterium acnes ATCC 6919

1

2.35

0.59

pH 7.3, 0.25% glucose

Propionibacterium acnes ATCC 6919

2

0.59

0.3

pH 5.5, 0.25% glucose

Staphylococcus aureus ATCC 6538

2

4.7

0.3

pH 7.3, 1% TSB

Staphylococcus aureus ATCC 6538

2

>300

0.15

pH 5.5, 0.25% glucose

Staphylococcus epidermidis ATCC 14990

2

300

9.38

pH 5.5, 0.25% glucose

Staphylococcus epidermidis ATCC 14990

2

4.7

0.59

pH 7.3, 1% TSB

Staphylococcus hominis ATCC 27844

1

4.7

1.18

pH 7.3, 1% TSB

Streptococcus pneumoniae ATCC 33400

1

4.7

2.35

pH 7.3, 1% TSB

Streptococcus pyogenes ATCC 12344

1

0.3

0.15

pH 7.3, 1% TSB

  1. *AA-sequence: Pal-GRRGGRGGRGRGR. **Now Finegoldia magna. Sensitivity of bacteria towards Pal-GR13 was tested in a CFU assay system in 10 mM NaP containing 0.25% glucose and 1% TSB, respectively, and, depending on the microbe, at pH 5.5, 6.0, 6.5 or pH 7.3. Representatives are shown. N: number of experiments.
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