Table 8 Antimicrobial activity spectrum of Pal-LCE-3B56–68*.

From: Cationic Intrinsically Disordered Antimicrobial Peptides (CIDAMPs) Represent a New Paradigm of Innate Defense with a Potential for Novel Anti-Infectives

Microorganism

n

LD100 (µg/mL)

LD90 (µg/mL)

Conditions

Burkholderia cepacia ATCC 25416

3

9.375

4.7

pH 7.3

Burkholderia cepacia ATCC 25416

3

>300

>300

pH 5.5

Escherichia coli ATCC11775

1

1.18

0.59

pH 7.3

Escherichia coli ATCC11775

1

>300/37.5**

0.3

pH 5.5

Klebsiella pneumoniae ATCC 13883

2

4.7

2.35

pH 7.3

Klebsiella pneumoniae ATCC 13883

2

9.375

0.15

pH 5.5

Pseudomonas aeruginosa ATCC10145

2

0.3

0.075

pH 5.5

Salmonella typhimurium ATCC 13311

2

2.35

1.18

pH 7.3

Salmonella typhimurium ATCC 13311

2

0.3

0.038

pH 5.5

Staphylococcus aureus ATCC 6538

2

0.15

<0.019

pH 5.5

Staphylococcus epidermidis ATCC 14990

2

0.3

0.3

pH 5.5

Streptococcus pneumoniae ATCC 33400

1

2.35

0.59

pH 7.3

Streptococcus pyogenes ATCC 12344

1

0.59

0.15

pH 6.0

Streptococcus pyogenes ATCC 12344

1

0.3

0.15

pH 7.3

  1. *AA-sequence: Pal-SHHRCCRSHRCRR. **Antimicrobial paradox (increased bacterial growth with increasing IDAMP-concentrations). Sensitivity of bacteria towards Pal-LCE-3B56–68 was tested in a CFU assay system in 10 mM NaP containing 0.25% glucose and, depending on the microbe, at a pH of 5.5, 6.0 or pH 7.3. Representatives are shown. n: number of experiments.
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