Table 5 Haplotypes of the cytokines genes and their distributions in the two cohorts.

From: Polymorphisms of cytokine genes and tuberculosis in two independent studies

Gene/haplotype

Han population

Tibetan population

Case(%) n = 1264

Control(%) n = 1210

P

OR

Case(%) n = 1226

Control(%) n = 1210

P

OR

IL1B

AGC

—

   

46.4 (3.8)

16.62 (1.4)

<0.001

2.82 (1.60–4.96)

GAC

75.4 (6.0)

86.6 (7.2)

0.251

0.83 (0.60–1.42)

91.4 (7.5)

86.6 (7.2)

0.785

1.04 (0.77–1.42)

GAG

551.5 (43.6)

492.1 (40.7)

0.097

1.15 (0.98–1.35)

615.0 (50.2)

492.1 (40.7)

<0.001

1.47 (1.25–1.72)

GGC

601.6 (47.6)

605.8 (50.1)

0.285

0.92 (0.78–1.08)

466.3 (38.0)

605.8 (50.1)

<0.001

0.61 (0.52–0.72)

Other*

35.4 (2.8)

25.6 (2.1)

?

?

7.0 (0.5)

8.9 (0.7)

?

?

IL6

AGA

674.3 (53.3)

615.9 (50.9)

0.259

1.01 (0.94–1.28)

531.0 (43.3)

615.9 (50.9)

<0.001

0.74 (0.63–0.87)

AGG

34.73 (2.7)

39.11 (3.2)

0.470

0.84 (0.53–1.34)

26.62 (2.2)

39.1 (3.2)

0.108

0.67 (0.40–1.10)

TGA

372.8 (29.5)

345.1 (22.7)

0.633

1.04 (0.88–1.24)

367.0 (29.9)

345.1 (28.5)

0.428

1.07 (0.90–1.28)

TGG

180.3 (14.3)

203.9 (16.9)

0.070

0.82 (0.66–1.02)

293.4 (23.9)

203.9 (16.9)

<0.001

1.56 (1.27–1.90)

Other*

2.0 (0.2)

6.0 (0.5)

?

?

8.0 (0.6)

6 (0.5)

?

?

TNF

CACGG

189.0 (15.6)

242.9 (19.2)

0.018

0.78 (0.63–0.96)

271.3 (22.1)

189.0 (15.6)

<0.001

1.54 (1.25–1.89)

CCCGA

—

   

53.3 (4.3)

22.0 (1.8)

<0.001

2.46 (1.49–4.07)

TCCAG

95.5 (7.9)

93.9 (7.4)

0.666

1.07 (0.79–1.44)

25.2 (2.1)

95.5 (7.9)

<0.001

0.25 (0.16–0.38)

TCCGG

716.6 (59.2)

718.1 (56.8)

0.221

1.11 (0.94–1.30)

591.2 (48.2)

716.6 (59.2)

<0.001

0.64 (0.55–0.75)

TCTGG

181.5 (0.2)

180.0 (14.2)

0.595

1.06 (0.85–1.33)

277.8 (22.7)

181.5 (15.0)

<0.001

1.67 (1.35–2.05)

Other*

27.6 (2.3)

29.1 (2.3)

  

7.2 (0.5)

5.6 (0.5)

  
  1. CI, confidence interval; OR, odds ratio.
  2. *Haplotypes with frequency <0.03 were pooled into this category.
Back to article page