Table 6 Association of cytokine genes with TB stratified by smoking status.

From: Polymorphisms of cytokine genes and tuberculosis in two independent studies

Gene/SNPs

Genetic model

Non-smoking

Genetic model

Smoking

P #

OR# (95% CI)

P #

OR# (95% CI)

IL1B

Allele

  

Allele

  

rs1143634G > A

 

0.166

1.63 (0.82–3.23)

 

0.986

—

rs16944G > A

 

0.883

1.02 (0.83–1.24)

 

<0.001

153.50 (37.79–623.61)

rs1143623C > G

 

0.430

1.08 (0.89–1.32)

 

0.451

1.12 (0.84–1.50)

IL6

Allele

  

Allele

  

rs17147230A > T

 

0.565

0.94 (0.77–1.15)

 

0.130

1.26 (0.94–1.69)

rs1800795G > C

 

0.226

0.26 (0.031–2.28)

 

<0.001

0.001 (0–0.10)

rs2069837A > G

 

0.046

0.77 (0.59–1.00)

 

<0.001

59.03 (8.18–426.17)

TNF

Allele

  

Allele

  

rs1799964T > C

 

0.017

1.35 (1.05–1.73)

 

0.427

0.86 (0.60–1.24)

rs1800630C > A

 

0.026

1.34 (1.04–1.72)

 

0.653

0.92 (0.62–1.34)

rs1799724C > T

 

0.804

0.97 (0.73–1.27)

 

0.654

0.91 (0.60–1.38)

rs1800629G > A

 

0.156

0.76 (0.52–1.11)

 

0.001

0.48 (0.30–0.75)

rs361525G > A

 

0.961

1.02 (0.47–2.21)

 

<0.001

0.26 (0.13–0.56)

  1. SNPs, single nucleotide polymorphisms; CI, confidence interval; OR, odds ratio.
  2. #Adjusted by age and sex.