Figure 4

The distribution of significantly up- and down-regulated genes in the HTAC 6 hr treatment when mapped on the KEGG global metabolic pathway. The green and red lines show genes that were significantly down- and up-regulated, respectively. The blue lines indicate genes that show both types of effects, likely due to the existence of gene paralogs with differential expression. Image created using KEGG Mapper80 at the KEGG website22.