Table 2 Clinicopathological characteristics according to BRAF V600E and SRC mutation status.

From: BRAF V600E and SRC mutations as molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer

Variable

Modality

BRAF V600E and SRC status

Both BRAF V600E and SRC wild-typea (N = 90)

BRAF V600E (N = 7)

SRC mutant (N = 14)

P-valueb

P-valuec

Age (years)

<65

52 (47)

3 (3)

7 (6)

0.667

0.999

≥65

38 (34)

4 (4)

7 (6)

  

Sex

Male

54 (49)

2 (2)

10 (9)

0.164

0.159

Female

36 (32)

5 (4)

4 (4)

  

Tumor size (mm)

<50

33 (30)

0 (0)

3 (3)

0.088

0.521

≥50

57 (51)

7 (6)

11 (10)

  

Pre-operative CEA (ng/ml)

<200

69 (62)

7 (6)

9 (8)

0.190

0.123

≥200

21 (19)

0 (0)

5 (4)

  

Primary tumor site

Right-sided

25 (23)

6 (5)

3 (3)

0.004

0.016

Left-sided

65 (58)

1 (1)

11 (10)

  

Histopathological grading

G1, 2

67 (60)

1 (1)

10 (9)

0.004

0.024

G3

23 (21)

6 (5)

4 (4)

  

T category

T2, 3

44 (40)

1 (1)

2 (2)

0.015

0.999

T4

46 (41)

6 (5)

12 (11)

  

N category

N0

13 (12)

0 (0)

2 (2)

0.558

0.533

N1, 2

77 (69)

7 (6)

12 (11)

  

M category

M1a

47 (42)

3 (3)

6 (5)

0.742

0.999

M1b

43 (39)

4 (4)

8 (7)

  

Liver metastasis

Absent

18 (16)

4 (4)

1 (1)

0.027

0.025

Present

72 (65)

3 (3)

13 (12)

  

Lung metastasis

Absent

63 (57)

4 (4)

10 (9)

0.764

0.638

Present

27 (24)

3 (3)

4 (4)

  

Peritoneal metastasis

Absent

74 (67)

4 (4)

11 (10)

0.273

0.354

Present

16 (14)

3 (3)

3 (3)

  

Liver-limited metastasis

Absent

51 (46)

6 (5)

7 (6)

0.269

0.174

Present

39 (35)

1 (1)

7 (6)

  

Number pf metastatic sites

1

51 (46)

5 (4)

8 (7)

0.748

0.656

≥2

39 (35)

2 (2)

6 (5)

  

Residual tumor

R0

41 (37)

1 (1)

3 (3)

0.080

0.593

R2

49 (44)

6 (5)

11 (10)

  
  1. aSix patients with BRAF non-V600E mutation were included.
  2. bThe three groups (BRAF and SRC wild-type, BRAF V600E, SRC mutant) were compared using a Pearson’s chi-squared test.
  3. cBRAF V600E versus SRC mutant were compared using a Fisher’s exact test (two-tailed).
Back to article page